JDP2

Across TCGA patient cohorts, JDP2 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible JDP2-associated genes across cancer lineages are Ku80, YAP, and p62 Lck ligand. Each is linked with JDP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both JDP2-to-partner and partner-to-JDP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by JDP2-low versus JDP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (JDP2→partner) and Y-score (partner→JDP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.398	+3.013	.001	.018	3	1
UCEC	YAP →	+0.166	+2.179	.034	.034	3	1
UCEC	p62 Lck ligand →	+0.511	+3.321	.002	.010	2	1
UCEC	EGFR →	-0.263	-3.321	.001	.010	1	1
UCEC	c-Met_pY1235 →	+0.108	+3.321	.005	.010	1	1
UCEC	Collagen-VI →	-0.304	-3.321	.004	.010	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Ku80 by JDP2 expression — UCEC

Explore this box plot interactively →