JCHAIN

Across TCGA patient cohorts, JCHAIN mutation is significantly associated with the RNA expression of many other genes, with 214 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible JCHAIN-associated genes across cancer lineages are MIR575, MIR4774, and RNA5SP414. Each is linked with JCHAIN in more than 2 cancer types. Because this analysis shows association rather than direction, both JCHAIN-to-partner and partner-to-JCHAIN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR575 grouped by JCHAIN-low versus JCHAIN-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (JCHAIN→partner) and Y-score (partner→JCHAIN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MIR575 →	+1.012	+5.474	<.001	.005	3	3
READ	MIR4774 →	+0.841	+6.257	<.001	.001	3	2
UCEC	RNA5SP414 →	+0.755	+2.670	<.001	.009	3	2
UCEC	TEX36-AS1 →	+0.143	+3.039	.007	.001	3	2
UCEC	RNA5SP419 →	+1.299	+3.077	<.001	.001	3	2
LGG	MIR4291 →	+0.443	+7.977	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 214 associations by consensus.

MIR575 by JCHAIN expression — LUSC

Explore this box plot interactively →