JCHAIN

Across TCGA patient cohorts, JCHAIN mutation is significantly associated with the immune_cell of many other genes, with 2 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible JCHAIN-associated genes across cancer lineages are CD8+ Tcm and Keratinocytes. Each is linked with JCHAIN in more than 1 cancer types. Because this analysis shows association rather than direction, both JCHAIN-to-partner and partner-to-JCHAIN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD8+ Tcm grouped by JCHAIN-low versus JCHAIN-high in LGG.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (JCHAIN→partner) and Y-score (partner→JCHAIN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	CD8+ Tcm →	+0.044	+6.380	<.001	.023	3	1
UCEC	Keratinocytes →	-0.016	-3.041	.039	.021	1	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

CD8+ Tcm by JCHAIN expression — LGG

Explore this box plot interactively →