JCHAIN

Across TCGA cell cohorts, JCHAIN mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible JCHAIN-associated genes across cancer lineages are OR6J1, NOBOX, and GPR119. Each is linked with JCHAIN in more than 1 cancer types. Because this analysis shows association rather than direction, both JCHAIN-to-partner and partner-to-JCHAIN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR6J1 grouped by JCHAIN-low versus JCHAIN-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (JCHAIN→partner) and Y-score (partner→JCHAIN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	OR6J1 →	+0.006	+5.643	<.001	.002	3	2
BLOOD_Lymphoma	NOBOX →	+0.006	+6.247	<.001	<.001	3	1
BLOOD_Lymphoma	GPR119 →	+0.025	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	KLHL40 →	+0.013	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	DCD →	+0.043	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	POTED →	+1.083	+4.867	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

OR6J1 by JCHAIN expression — BLOOD_Lymphoma

Explore this box plot interactively →