JCAD

Across TCGA cell cohorts, JCAD mutation is significantly associated with the RNA expression of many other genes, with 386 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible JCAD-associated genes across cancer lineages are LYZL1, TBL1Y, and RAX. Each is linked with JCAD in more than 2 cancer types. Because this analysis shows association rather than direction, both JCAD-to-partner and partner-to-JCAD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LYZL1 grouped by JCAD-low versus JCAD-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (JCAD→partner) and Y-score (partner→JCAD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	LYZL1 →	+0.026	+4.643	<.001	.008	3	2
PANCREAS	TBL1Y →	+0.004	+4.029	<.001	.007	3	2
CNS	RAX →	+0.241	+3.321	.001	.006	3	2
CNS	TAFA4 →	+1.582	+4.096	<.001	.001	3	2
CNS	RD3L →	+0.160	+3.981	<.001	.001	3	2
LARGE_INTESTINE	INTS10 →	+0.711	+3.169	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 386 associations by consensus.

LYZL1 by JCAD expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →