JCAD

Across TCGA cell cohorts, JCAD mutation is significantly associated with the mutation status of many other genes, with 3,817 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible JCAD-associated genes across cancer lineages are NID2, DLGAP4, and RP1. Each is linked with JCAD in more than 4 cancer types. Because this analysis shows association rather than direction, both JCAD-to-partner and partner-to-JCAD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NID2 grouped by JCAD-low versus JCAD-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (JCAD→partner) and Y-score (partner→JCAD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	NID2 →	+3.906	+3.906	.003	.003	1	5
BLOOD_Lymphoma	DLGAP4 →	+4.554	+4.247	.001	.001	1	5
LARGE_INTESTINE	RP1 →	+2.291	+4.700	<.001	<.001	1	5
CNS	TRPM6 →	+3.263	+3.554	.005	.005	1	5
LUNG_NSCLC_LUAD	PCDH15 →	+1.276	+2.754	.005	.005	1	5
LARGE_INTESTINE	FBXL7 →	+2.050	+2.050	.003	.003	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,817 associations by consensus.

NID2 by JCAD expression — PANCREAS

Explore this box plot interactively →