JAZF1

Across TCGA patient cohorts, JAZF1 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible JAZF1-associated genes across cancer lineages are Stathmin, 4E-BP1, and EGFR_pY1068. Each is linked with JAZF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both JAZF1-to-partner and partner-to-JAZF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Stathmin grouped by JAZF1-low versus JAZF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (JAZF1→partner) and Y-score (partner→JAZF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Stathmin →	+0.128	+2.833	.017	.034	3	2
UCEC	4E-BP1 →	+0.397	+3.321	<.001	.009	3	2
UCEC	EGFR_pY1068 →	-0.333	-2.906	<.001	.001	3	1
UCEC	eIF4G →	+0.244	+2.321	.045	.033	3	1
UCEC	ERK2 →	+0.195	+2.000	.010	.010	3	1
UCEC	FOXO3a_pS318_S321 →	-0.116	-1.797	.017	.025	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Stathmin by JAZF1 expression — UCEC

Explore this box plot interactively →