JARID2

Across TCGA patient cohorts, JARID2 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible JARID2-associated genes across cancer lineages are 4E-BP1_pT37_T46, ERK2, and INPP4B. Each is linked with JARID2 in more than 2 cancer types. Because this analysis shows association rather than direction, both JARID2-to-partner and partner-to-JARID2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1_pT37_T46 grouped by JARID2-low versus JARID2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (JARID2→partner) and Y-score (partner→JARID2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1_pT37_T46 →	-0.210	-1.266	.040	.049	3	3
UCEC	ERK2 →	+0.189	+2.321	<.001	<.001	3	2
COAD	INPP4B →	-0.425	-2.313	.011	.035	3	2
UCEC	MEK1 →	+0.367	+1.584	<.001	<.001	3	2
UCEC	4E-BP1 →	+0.156	+1.678	.034	.019	3	2
COAD	EGFR_pY1068 →	-0.332	-2.313	.024	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

4E-BP1_pT37_T46 by JARID2 expression — UCEC

Explore this box plot interactively →