JAML

Across TCGA patient cohorts, JAML protein abundance is significantly associated with the RNA expression of many other genes, with 7,872 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible JAML-associated genes across cancer lineages are PSMB5, CEACAM4, and MSH6. Each is linked with JAML in more than 2 cancer types. Because this analysis shows association rather than direction, both JAML-to-partner and partner-to-JAML results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, JAML versus PSMB5 in PDAC, with a Pearson correlation of -0.65.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (JAML→partner) and Y-score (partner→JAML) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	PSMB5 →	-0.459	-0.945	.006	.003	3	3
LSCC	CEACAM4 →	+0.767	+0.466	<.001	<.001	3	3
LSCC	MSH6 →	-0.447	-0.344	<.001	<.001	3	3
BRCA	ARHGEF6 →	+1.879	+0.928	<.001	.005	3	3
LSCC	COQ3 →	-0.539	-0.368	<.001	<.001	3	3
LSCC	TRIM45 →	-1.012	-0.579	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,872 associations by consensus.

JAML vs PSMB5 — PDAC

Explore this scatter interactively →