JAML

Across TCGA patient cohorts, JAML mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible JAML-associated genes across cancer lineages are STAT3_pY705, A-Raf_pS299, and Ku80. Each is linked with JAML in more than 1 cancer types. Because this analysis shows association rather than direction, both JAML-to-partner and partner-to-JAML results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by JAML-low versus JAML-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (JAML→partner) and Y-score (partner→JAML) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.532	-3.584	<.001	.002	3	2
UCEC	A-Raf_pS299 →	-0.134	-3.169	.020	.019	3	1
UCEC	Ku80 →	+0.268	+2.472	.018	.011	3	1
UCEC	p70-S6K_pT389 →	-0.190	-2.459	.038	.020	3	1
UCEC	PDK1_pS241 →	+0.166	+2.321	.044	.034	3	1
UCEC	Tuberin →	+0.387	+2.459	.002	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

STAT3_pY705 by JAML expression — UCEC

Explore this box plot interactively →