JAML

Across TCGA cell cohorts, JAML mutation is significantly associated with the RNA expression of many other genes, with 29 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible JAML-associated genes across cancer lineages are SLC32A1, PHOX2B, and TCF21. Each is linked with JAML in more than 1 cancer types. Because this analysis shows association rather than direction, both JAML-to-partner and partner-to-JAML results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC32A1 grouped by JAML-low versus JAML-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (JAML→partner) and Y-score (partner→JAML) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SLC32A1 →	+0.792	+3.901	<.001	.006	3	1
BLOOD_Leukemia	PHOX2B →	+0.018	+4.365	<.001	.002	3	1
BLOOD_Leukemia	TCF21 →	+0.008	+3.705	.002	.007	3	1
BLOOD_Leukemia	MYOG →	+0.029	+3.769	.006	.008	3	1
BLOOD_Leukemia	PSG8 →	+0.039	+3.959	<.001	.005	3	1
BLOOD_Leukemia	GFRA4 →	+0.249	+4.824	.003	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

SLC32A1 by JAML expression — BLOOD_Leukemia

Explore this box plot interactively →