JAM3

Across TCGA patient cohorts, JAM3 mutation is significantly associated with the RNA expression of many other genes, with 1,085 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible JAM3-associated genes across cancer lineages are PGBD4P2, RNA5SP91, and MTCO3P45. Each is linked with JAM3 in more than 1 cancer types. Because this analysis shows association rather than direction, both JAM3-to-partner and partner-to-JAM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PGBD4P2 grouped by JAM3-low versus JAM3-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (JAM3→partner) and Y-score (partner→JAM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	PGBD4P2 →	+0.162	+6.257	<.001	.001	3	2
LIHC	RNA5SP91 →	+0.349	+5.878	<.001	.002	3	2
LUAD	MTCO3P45 →	+0.111	+5.888	<.001	.002	3	2
BRCA	RN7SKP221 →	+0.099	+8.471	<.001	.005	3	2
BRCA	TRDD1 →	+1.367	+9.057	<.001	.003	3	2
BLCA	RNU6-552P →	+0.461	+5.106	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,085 associations by consensus.

PGBD4P2 by JAM3 expression — READ

Explore this box plot interactively →