JAM3

Across TCGA patient cohorts, JAM3 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible JAM3-associated genes across cancer lineages are ERK2, MEK1, and MSH2. Each is linked with JAM3 in more than 1 cancer types. Because this analysis shows association rather than direction, both JAM3-to-partner and partner-to-JAM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by JAM3-low versus JAM3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (JAM3→partner) and Y-score (partner→JAM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.194	+3.321	.012	.010	3	1
UCEC	MEK1 →	+0.472	+2.415	.001	.003	3	1
UCEC	MSH2 →	-0.278	-3.295	.002	.009	3	1
UCEC	p62 Lck ligand →	+0.327	+2.331	.012	.019	3	1
UCEC	PDCD4 →	-0.539	-1.874	.004	.049	3	1
UCEC	Rab11 →	-0.148	-2.095	.011	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

ERK2 by JAM3 expression — UCEC

Explore this box plot interactively →