JAM2

Across TCGA cell cohorts, JAM2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,501 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible JAM2-associated GO terms across cancer lineages are Regulation of cytotoxic T cell degranulation, Negative regulation of cytotoxic T cell degranulation, and Positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled. Each is linked with JAM2 in more than 7 cancer types. Because this analysis shows association rather than direction, both JAM2-to-partner and partner-to-JAM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of cytotoxic T cell degranulation grouped by JAM2-low versus JAM2-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (JAM2→partner) and Y-score (partner→JAM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Regulation of cytotoxic T cell degranulation →	-1.271	-1.034	<.001	.008	3	8
SKIN	Negative regulation of cytotoxic T cell degranulation →	-1.271	-1.034	<.001	.008	3	8
LUNG_NSCLC_LUAD	Positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled →	+0.092	+0.474	<.001	.004	3	7
SKIN	Positive regulation of termination of DNA-templated transcription →	+0.080	+1.032	.002	.007	3	7
STOMACH	Regulation of termination of RNA polymerase II transcription, poly(A)-coupled →	+0.138	+0.142	<.001	.009	2	8
LUNG_SCLC	Cellular response to fatty acid →	-0.166	-1.716	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,501 associations by consensus.

Regulation of cytotoxic T cell degranulation by JAM2 expression — SKIN

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