JAM2

Across TCGA cell cohorts, JAM2 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible JAM2-associated genes across cancer lineages are CDX4, PPEF2, and KRTAP5-10. Each is linked with JAM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both JAM2-to-partner and partner-to-JAM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDX4 grouped by JAM2-low versus JAM2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (JAM2→partner) and Y-score (partner→JAM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CDX4 →	+0.009	+3.632	<.001	.003	3	1
LARGE_INTESTINE	PPEF2 →	+0.038	+3.736	<.001	.007	3	1
LARGE_INTESTINE	KRTAP5-10 →	+0.048	+3.807	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

CDX4 by JAM2 expression — LARGE_INTESTINE

Explore this box plot interactively →