JAKMIP2

Across TCGA patient cohorts, JAKMIP2 mutation is significantly associated with the total protein of many other genes, with 68 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible JAKMIP2-associated genes across cancer lineages are eEF2, STAT3_pY705, and FASN. Each is linked with JAKMIP2 in more than 2 cancer types. Because this analysis shows association rather than direction, both JAKMIP2-to-partner and partner-to-JAKMIP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by JAKMIP2-low versus JAKMIP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (JAKMIP2→partner) and Y-score (partner→JAKMIP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.207	+1.807	.042	.024	3	3
UCEC	STAT3_pY705 →	-0.396	-2.000	<.001	<.001	3	2
UCEC	FASN →	+0.280	+1.321	.012	.027	3	2
UCEC	FoxM1 →	+0.200	+1.398	.006	.004	3	2
UCEC	HER2_pY1248 →	-0.160	-1.398	.034	.004	3	2
UCEC	MEK1 →	+0.383	+2.662	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 68 associations by consensus.

eEF2 by JAKMIP2 expression — UCEC

Explore this box plot interactively →