JAKMIP2

Across TCGA cell cohorts, JAKMIP2 mutation is significantly associated with the RNA expression of many other genes, with 233 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible JAKMIP2-associated genes across cancer lineages are C9orf92, AVP, and ZAN. Each is linked with JAKMIP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both JAKMIP2-to-partner and partner-to-JAKMIP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C9orf92 grouped by JAKMIP2-low versus JAKMIP2-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (JAKMIP2→partner) and Y-score (partner→JAKMIP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	C9orf92 →	+0.235	+4.058	<.001	.009	3	2
SOFT_TISSUE	AVP →	+0.130	+5.977	<.001	.001	3	1
SOFT_TISSUE	ZAN →	+0.006	+5.369	<.001	.004	3	1
SOFT_TISSUE	FTMT →	+0.086	+5.977	<.001	.001	3	1
CNS	PRAMEF26 →	+0.270	+5.754	.005	.002	3	1
LARGE_INTESTINE	GCAT →	+1.066	+2.158	.002	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 233 associations by consensus.

C9orf92 by JAKMIP2 expression — BLOOD_Lymphoma

Explore this box plot interactively →