JAKMIP2

Across TCGA cell cohorts, JAKMIP2 mutation is significantly associated with the mutation status of many other genes, with 4,516 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible JAKMIP2-associated genes across cancer lineages are SPG11, ETV6, and IGSF1. Each is linked with JAKMIP2 in more than 4 cancer types. Because this analysis shows association rather than direction, both JAKMIP2-to-partner and partner-to-JAKMIP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPG11 grouped by JAKMIP2-low versus JAKMIP2-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (JAKMIP2→partner) and Y-score (partner→JAKMIP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	SPG11 →	+4.392	+4.954	.008	.008	1	5
CNS	ETV6 →	+4.614	+4.614	.006	.006	1	5
LARGE_INTESTINE	IGSF1 →	+2.278	+2.095	<.001	<.001	1	5
BLOOD_Lymphoma	CNTNAP2 →	+2.386	+3.129	.002	.002	1	5
LARGE_INTESTINE	DCHS2 →	+1.246	+1.697	.008	.008	1	5
SOFT_TISSUE	AHNAK2 →	+3.329	+4.562	.003	.003	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,516 associations by consensus.

SPG11 by JAKMIP2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →