JAKMIP1

Across TCGA patient cohorts, JAKMIP1 mutation is significantly associated with the total protein of many other genes, with 73 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible JAKMIP1-associated genes across cancer lineages are ASNS, Caspase-7-cleavedD198, and Cyclin-E2. Each is linked with JAKMIP1 in more than 3 cancer types. Because this analysis shows association rather than direction, both JAKMIP1-to-partner and partner-to-JAKMIP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by JAKMIP1-low versus JAKMIP1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (JAKMIP1→partner) and Y-score (partner→JAKMIP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ASNS →	+0.469	+1.882	.004	.031	3	4
COAD	Caspase-7-cleavedD198 →	+1.406	+3.016	<.001	.018	3	4
COAD	Cyclin-E2 →	+0.197	+3.025	.043	.018	3	3
UCEC	CDK1 →	+0.111	+1.222	.023	.035	3	3
STAD	P-Cadherin →	-0.154	-2.807	.006	.003	3	2
STAD	Rictor_pT1135 →	-0.179	-2.305	.002	.032	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 73 associations by consensus.

ASNS by JAKMIP1 expression — COAD

Explore this box plot interactively →