JAK3

Across TCGA patient cohorts, JAK3 RNA expression is significantly associated with the protein abundance of many other proteins, with 22,101 significant associations in total. GBM shows the largest number of these associations.

The most reproducible JAK3-associated proteins across cancer lineages are MYO1F, MYO1G, and NCF1. Each is linked with JAK3 in more than 9 cancer types. Because this analysis shows association rather than direction, both JAK3-to-partner and partner-to-JAK3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, JAK3 versus MYO1F in GBM, with a Pearson correlation of 0.85.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (JAK3→partner) and Y-score (partner→JAK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MYO1F →	+0.802	+1.360	<.001	<.001	3	10
GBM	MYO1G →	+0.768	+1.244	<.001	<.001	3	10
COAD	NCF1 →	+0.692	+0.821	<.001	<.001	3	10
GBM	ARHGAP45 →	+0.710	+1.306	<.001	<.001	3	10
GBM	ARHGAP9 →	+0.629	+1.340	<.001	<.001	3	10
BRCA	STK17B →	+0.437	+0.950	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 22,101 associations by consensus.

JAK3 vs MYO1F — GBM

Explore this scatter interactively →