JAK3

Across TCGA patient cohorts, JAK3 protein abundance is significantly associated with the RNA expression of many other genes, with 16,485 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible JAK3-associated genes across cancer lineages are EBI3, SIGLEC10, and SLA. Each is linked with JAK3 in more than 6 cancer types. Because this analysis shows association rather than direction, both JAK3-to-partner and partner-to-JAK3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, JAK3 versus EBI3 in GBM, with a Pearson correlation of 0.31.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (JAK3→partner) and Y-score (partner→JAK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	EBI3 →	+1.007	+0.590	<.001	<.001	3	7
UCEC	SIGLEC10 →	+1.073	+0.691	.006	.001	3	7
BRCA	SLA →	+0.907	+0.577	<.001	<.001	3	7
BRCA	CSF2RB →	+1.227	+0.528	.002	<.001	3	6
LSCC	SLA2 →	+0.843	+0.461	<.001	<.001	3	6
LUAD	MAP4K1 →	+0.815	+0.418	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,485 associations by consensus.

JAK3 vs EBI3 — GBM

Explore this scatter interactively →