JAK3

Across TCGA patient cohorts, JAK3 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible JAK3-associated genes across cancer lineages are PDCD4, PREX1, and Stathmin. Each is linked with JAK3 in more than 2 cancer types. Because this analysis shows association rather than direction, both JAK3-to-partner and partner-to-JAK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by JAK3-low versus JAK3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (JAK3→partner) and Y-score (partner→JAK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PDCD4 →	-0.421	-1.991	.013	.031	3	2
COAD	PREX1 →	+0.174	+2.725	.039	.003	3	2
COAD	Stathmin →	+0.155	+2.708	.012	.003	3	2
COAD	Bad_pS112 →	-0.179	-1.991	.024	.031	2	3
UCEC	Notch1 →	+0.113	+1.523	.011	.008	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.293	-1.510	.041	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

PDCD4 by JAK3 expression — COAD

Explore this box plot interactively →