JAK3

Across TCGA cell cohorts, JAK3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,037 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible JAK3-associated GO terms across cancer lineages are Cilium or flagellum-dependent cell motility, Cilium-dependent cell motility, and Regulation of myoblast fusion. Each is linked with JAK3 in more than 9 cancer types. Because this analysis shows association rather than direction, both JAK3-to-partner and partner-to-JAK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cilium or flagellum-dependent cell motility grouped by JAK3-low versus JAK3-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (JAK3→partner) and Y-score (partner→JAK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Cilium or flagellum-dependent cell motility →	-0.106	-0.702	<.001	.001	3	10
UPPER_AERODIGESTIVE_TRACT	Cilium-dependent cell motility →	-0.106	-0.702	<.001	.001	3	10
UPPER_AERODIGESTIVE_TRACT	Regulation of myoblast fusion →	+0.127	+0.925	<.001	<.001	3	9
PANCREAS	Response to type I interferon →	+0.103	+0.638	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Sperm motility →	-0.117	-0.635	.001	.003	3	9
UPPER_AERODIGESTIVE_TRACT	Flagellated sperm motility →	-0.117	-0.635	.001	.003	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,037 associations by consensus.

Cilium or flagellum-dependent cell motility by JAK3 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →