JAK3

Across TCGA cell cohorts, JAK3 mutation is significantly associated with the RNA expression of many other genes, with 496 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible JAK3-associated genes across cancer lineages are VCY1B, ZIC5, and ALOX12B. Each is linked with JAK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both JAK3-to-partner and partner-to-JAK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VCY1B grouped by JAK3-low versus JAK3-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (JAK3→partner) and Y-score (partner→JAK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	VCY1B →	+1.066	+3.836	.002	.001	3	2
BLOOD_Leukemia	ZIC5 →	+0.423	+2.841	.001	.002	3	2
BLOOD_Leukemia	ALOX12B →	+0.533	+3.184	<.001	.007	3	2
LARGE_INTESTINE	CBY1 →	+0.669	+3.451	<.001	.002	3	2
LARGE_INTESTINE	PRIMPOL →	+0.558	+3.364	.005	.002	3	2
LARGE_INTESTINE	SLC38A8 →	+0.493	+3.404	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 496 associations by consensus.

VCY1B by JAK3 expression — BREAST

Explore this box plot interactively →