JAK2

Across TCGA patient cohorts, JAK2 protein abundance is significantly associated with the RNA expression of many other genes, with 13,056 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible JAK2-associated genes across cancer lineages are ARHGAP9, FGD2, and RCSD1. Each is linked with JAK2 in more than 6 cancer types. Because this analysis shows association rather than direction, both JAK2-to-partner and partner-to-JAK2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, JAK2 versus ARHGAP9 in LSCC, with a Pearson correlation of 0.75.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (JAK2→partner) and Y-score (partner→JAK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ARHGAP9 →	+0.850	+0.408	<.001	<.001	3	7
GBM	FGD2 →	+0.985	+0.347	<.001	<.001	3	7
LSCC	RCSD1 →	+0.889	+0.432	<.001	<.001	3	7
BRCA	GIMAP1 →	+0.673	+0.301	<.001	<.001	3	7
LSCC	S1PR4 →	+0.883	+0.388	<.001	<.001	3	7
UCEC	TPI1 →	-0.994	-0.274	.005	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,056 associations by consensus.

JAK2 vs ARHGAP9 — LSCC

Explore this scatter interactively →