JAK2

Across TCGA patient cohorts, JAK2 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible JAK2-associated genes across cancer lineages are Cyclin-E2, eEF2, and PCNA. Each is linked with JAK2 in more than 2 cancer types. Because this analysis shows association rather than direction, both JAK2-to-partner and partner-to-JAK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E2 grouped by JAK2-low versus JAK2-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (JAK2→partner) and Y-score (partner→JAK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Cyclin-E2 →	+0.157	+2.828	.034	.035	3	3
SKCM	eEF2 →	+0.358	+3.169	.046	.019	3	3
COAD	PCNA →	+0.269	+3.008	.036	.019	3	3
UCEC	Cyclin-B1 →	+0.763	+2.584	<.001	<.001	3	3
COAD	PDCD4 →	-0.545	-2.991	.012	.036	3	2
UCEC	MEK1 →	+0.461	+1.999	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

Cyclin-E2 by JAK2 expression — STAD

Explore this box plot interactively →