JAK2

Across TCGA cell cohorts, JAK2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,058 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible JAK2-associated GO terms across cancer lineages are Positive regulation of growth hormone receptor signaling pathway, Dephosphorylation, and Post-Golgi vesicle-mediated transport. Each is linked with JAK2 in more than 11 cancer types. Because this analysis shows association rather than direction, both JAK2-to-partner and partner-to-JAK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of growth hormone receptor signaling pathway grouped by JAK2-low versus JAK2-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (JAK2→partner) and Y-score (partner→JAK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Positive regulation of growth hormone receptor signaling pathway →	+1.166	+1.296	<.001	<.001	3	11
LIVER	Dephosphorylation →	+0.059	+0.801	.001	.005	2	12
SKIN	Post-Golgi vesicle-mediated transport →	+0.047	+0.615	<.001	.001	3	11
BLOOD_Lymphoma	Vesicle-mediated transport to the plasma membrane →	+0.046	+1.252	<.001	<.001	3	10
SOFT_TISSUE	Cytosolic transport →	+0.067	+0.784	<.001	<.001	3	10
OVARY	Regulation of post-transcriptional gene silencing →	+0.100	+0.828	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,058 associations by consensus.

Positive regulation of growth hormone receptor signaling pathway by JAK2 expression — STOMACH

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