JAK2

Across TCGA cell cohorts, JAK2 mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible JAK2-associated genes across cancer lineages are TTLL8, WFDC11, and DPPA2. Each is linked with JAK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both JAK2-to-partner and partner-to-JAK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TTLL8 grouped by JAK2-low versus JAK2-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (JAK2→partner) and Y-score (partner→JAK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	TTLL8 →	+0.006	+4.906	<.001	.006	3	1
OESOPHAGUS	WFDC11 →	+0.046	+4.906	<.001	.006	3	1
BLOOD_Lymphoma	DPPA2 →	+0.218	+4.523	<.001	.004	3	1
BLOOD_Lymphoma	FGF4 →	+0.022	+5.247	<.001	.001	3	1
LUNG_NSCLC_LUAD	USP29 →	+0.012	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR4N4 →	+0.277	+5.189	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

TTLL8 by JAK2 expression — OESOPHAGUS

Explore this box plot interactively →