JAGN1

Across TCGA pan-cancer cohorts, JAGN1 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of JAGN1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where JAGN1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types JAGN1 is over-expressed in tumor, although a few such as LUAD and PDAC show the opposite, repressed pattern.

HNSC, LUAD, and PDAC are the cancer types where JAGN1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in JAGN1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	II,III,IV	+0.273	.001	8	view →
LUAD	All	II,III,IV	−0.249	.001	5	view →
PDAC	All	All	−0.564	<.001	4	view →
CCRCC	All	All	−0.180	.008	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

JAGN1–HNSC

Open the HNSC breakdown →