JAG1

Across TCGA patient cohorts, JAG1 mutation is significantly associated with the total protein of many other genes, with 73 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible JAG1-associated genes across cancer lineages are INPP4B, Cyclin-E2, and p27_pT157. Each is linked with JAG1 in more than 2 cancer types. Because this analysis shows association rather than direction, both JAG1-to-partner and partner-to-JAG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by JAG1-low versus JAG1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (JAG1→partner) and Y-score (partner→JAG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	INPP4B →	-0.382	-2.321	.004	.032	3	3
UCEC	Cyclin-E2 →	+0.136	+1.179	.005	.041	3	3
COAD	p27_pT157 →	+0.145	+3.321	.005	.009	3	3
COAD	PDCD4 →	-0.375	-1.898	.014	.016	3	3
BLCA	HER3_pY1289 →	+0.131	+2.321	.015	.035	2	3
SKCM	Stathmin →	+0.200	+2.195	.025	.032	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 73 associations by consensus.

INPP4B by JAG1 expression — COAD

Explore this box plot interactively →