JAG1

Across TCGA cell cohorts, JAG1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,823 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible JAG1-associated GO terms across cancer lineages are Pulmonary artery morphogenesis, Negative regulation of endothelial cell differentiation, and Neuronal stem cell population maintenance. Each is linked with JAG1 in more than 17 cancer types. Because this analysis shows association rather than direction, both JAG1-to-partner and partner-to-JAG1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Pulmonary artery morphogenesis grouped by JAG1-low versus JAG1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (JAG1→partner) and Y-score (partner→JAG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Pulmonary artery morphogenesis →	+1.369	+2.718	<.001	<.001	3	18
STOMACH	Negative regulation of endothelial cell differentiation →	+0.234	+1.940	<.001	<.001	3	16
LIVER	Neuronal stem cell population maintenance →	+0.249	+3.274	.001	.002	3	14
KIDNEY	Cell differentiation involved in kidney development →	+0.191	+1.973	<.001	<.001	3	13
PANCREAS	Podocyte development →	+0.284	+2.380	<.001	<.001	3	13
LUNG_NSCLC_LUAD	Distal tubule development →	+0.217	+1.458	.005	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,823 associations by consensus.

Pulmonary artery morphogenesis by JAG1 expression — LUNG_NSCLC_LUSC

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