JADE3

Across TCGA patient cohorts, JADE3 protein abundance is significantly associated with the RNA expression of many other genes, with 9,693 significant associations in total. GBM shows the largest number of these associations.

The most reproducible JADE3-associated genes across cancer lineages are DNA2, LAS1L, and DNMT3B. Each is linked with JADE3 in more than 3 cancer types. Because this analysis shows association rather than direction, both JADE3-to-partner and partner-to-JADE3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, JADE3 versus DNA2 in GBM, with a Pearson correlation of 0.54.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (JADE3→partner) and Y-score (partner→JADE3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	DNA2 →	+0.854	+0.805	<.001	<.001	3	4
LSCC	LAS1L →	+0.384	+0.471	.001	<.001	3	4
UCEC	DNMT3B →	+1.131	+0.390	<.001	<.001	3	4
GBM	MSH2 →	+0.555	+0.570	<.001	<.001	3	4
GBM	KIAA1549 →	+0.803	+0.489	<.001	<.001	3	4
PDAC	GPT2 →	+1.256	+0.559	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,693 associations by consensus.

JADE3 vs DNA2 — GBM

Explore this scatter interactively →