JADE3

Across TCGA patient cohorts, JADE3 mutation is significantly associated with the RNA expression of many other genes, with 2,617 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible JADE3-associated genes across cancer lineages are RNA5SP413, MIR4686, and RNU6-768P. Each is linked with JADE3 in more than 2 cancer types. Because this analysis shows association rather than direction, both JADE3-to-partner and partner-to-JADE3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP413 grouped by JADE3-low versus JADE3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (JADE3→partner) and Y-score (partner→JADE3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP413 →	+0.795	+1.384	<.001	.003	3	3
CESC	MIR4686 →	+0.368	+3.542	.004	.007	3	2
LGG	RNU6-768P →	+0.268	+7.977	<.001	.007	3	2
UCEC	POLE2 →	+0.415	+2.159	.001	<.001	3	2
UCEC	E2F1 →	+0.690	+3.960	<.001	<.001	3	2
UCEC	NUTF2 →	+0.252	+1.430	.004	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,617 associations by consensus.

RNA5SP413 by JADE3 expression — UCEC

Explore this box plot interactively →