JADE3

Across TCGA patient cohorts, JADE3 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible JADE3-associated genes across cancer lineages are Cyclin-B1, DJ-1, and eIF4E. Each is linked with JADE3 in more than 1 cancer types. Because this analysis shows association rather than direction, both JADE3-to-partner and partner-to-JADE3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by JADE3-low versus JADE3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (JADE3→partner) and Y-score (partner→JADE3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.454	+1.716	.012	.003	3	2
UCEC	DJ-1 →	+0.110	+1.750	.042	.049	3	2
UCEC	eIF4E →	+0.205	+2.000	.002	<.001	3	1
UCEC	JNK_pT183_Y185 →	-0.143	-1.502	.008	.027	3	1
UCEC	MEK1 →	+0.381	+3.087	.001	<.001	3	1
UCEC	MSH2 →	-0.206	-1.674	.005	.040	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Cyclin-B1 by JADE3 expression — UCEC

Explore this box plot interactively →