JADE2

Across TCGA cell cohorts, JADE2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,156 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible JADE2-associated GO terms across cancer lineages are Regulation of anaphase-promoting complex-dependent catabolic process, Negative regulation of mitotic cell cycle phase transition, and Cellular response to environmental stimulus. Each is linked with JADE2 in more than 9 cancer types. Because this analysis shows association rather than direction, both JADE2-to-partner and partner-to-JADE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of anaphase-promoting complex-dependent catabolic process grouped by JADE2-low versus JADE2-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (JADE2→partner) and Y-score (partner→JADE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Regulation of anaphase-promoting complex-dependent catabolic process →	+0.091	+0.789	<.001	<.001	3	10
LARGE_INTESTINE	Negative regulation of mitotic cell cycle phase transition →	+0.077	+1.228	<.001	<.001	3	10
SOFT_TISSUE	Cellular response to environmental stimulus →	+0.045	+1.713	<.001	<.001	3	10
LARGE_INTESTINE	Signal transduction in response to DNA damage →	+0.060	+0.955	<.001	<.001	3	10
BREAST	Metaphase/anaphase transition of cell cycle →	+0.124	+1.235	<.001	<.001	3	10
SOFT_TISSUE	Cellular response to abiotic stimulus →	+0.045	+1.713	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,156 associations by consensus.

Regulation of anaphase-promoting complex-dependent catabolic process by JADE2 expression — LARGE_INTESTINE

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