IZUMO4

Across TCGA patient cohorts, IZUMO4 RNA expression is significantly associated with the protein abundance of many other proteins, with 9,326 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible IZUMO4-associated proteins across cancer lineages are PDE3A_S520, MYLK_S1209, and NES_S1590. Each is linked with IZUMO4 in more than 2 cancer types. Because this analysis shows association rather than direction, both IZUMO4-to-partner and partner-to-IZUMO4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IZUMO4 versus PDE3A_S520 in OV, with a Pearson correlation of -0.45.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IZUMO4→partner) and Y-score (partner→IZUMO4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PDE3A_S520 →	-0.900	-0.473	.002	.002	3	3
LSCC	MYLK_S1209 →	-0.388	-0.426	.002	.002	3	3
LSCC	NES_S1590 →	-1.018	-0.652	<.001	<.001	3	3
LSCC	NFATC4_T124 →	-0.449	-0.529	.002	<.001	3	3
LUAD	PDLIM2_S178 →	-0.754	-0.589	.001	.001	3	3
CCRCC	PEAK1 →	-0.275	-0.377	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,326 associations by consensus.

IZUMO4 vs PDE3A_S520 — OV

Explore this scatter interactively →