IZUMO4

Across TCGA patient cohorts, IZUMO4 protein abundance is significantly associated with the RNA expression of many other genes, with 101 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible IZUMO4-associated genes across cancer lineages are NSMCE4A, MT1G, and SUCLA2. Each is linked with IZUMO4 in more than 1 cancer types. Because this analysis shows association rather than direction, both IZUMO4-to-partner and partner-to-IZUMO4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IZUMO4 versus NSMCE4A in BRCA, with a Pearson correlation of -0.94.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IZUMO4→partner) and Y-score (partner→IZUMO4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NSMCE4A →	-0.940	-1.269	<.001	.004	3	1
BRCA	MT1G →	+2.663	+1.269	.005	.004	3	1
BRCA	SUCLA2 →	+0.503	+1.246	.008	.005	3	1
BRCA	RAMAC →	-0.873	-1.199	.005	.006	3	1
BRCA	RSL1D1 →	-0.740	-1.269	.003	.004	3	1
BRCA	CCDC13-AS1 →	+0.386	+1.269	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 101 associations by consensus.

IZUMO4 vs NSMCE4A — BRCA

Explore this scatter interactively →