IZUMO4

Across TCGA patient cohorts, IZUMO4 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IZUMO4-associated genes across cancer lineages are JNK2, p62 Lck ligand, and p70-S6K. Each is linked with IZUMO4 in more than 1 cancer types. Because this analysis shows association rather than direction, both IZUMO4-to-partner and partner-to-IZUMO4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by IZUMO4-low versus IZUMO4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IZUMO4→partner) and Y-score (partner→IZUMO4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.287	+2.584	.001	.011	3	1
UCEC	p62 Lck ligand →	+0.398	+2.584	.008	.011	3	1
UCEC	p70-S6K →	+0.201	+3.727	.025	<.001	3	1
UCEC	Rad50 →	-0.259	-2.584	.021	.011	3	1
UCEC	Annexin-1 →	+0.513	+2.189	.036	.034	3	1
UCEC	4E-BP1_pT37_T46 →	-0.528	-3.321	.002	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

JNK2 by IZUMO4 expression — UCEC

Explore this box plot interactively →