IZUMO4

Across TCGA cell cohorts, IZUMO4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,836 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible IZUMO4-associated GO terms across cancer lineages are Cilium movement involved in cell motility, Cilium or flagellum-dependent cell motility, and Cilium-dependent cell motility. Each is linked with IZUMO4 in more than 9 cancer types. Because this analysis shows association rather than direction, both IZUMO4-to-partner and partner-to-IZUMO4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cilium movement involved in cell motility grouped by IZUMO4-low versus IZUMO4-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IZUMO4→partner) and Y-score (partner→IZUMO4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Cilium movement involved in cell motility →	-0.086	-0.452	<.001	<.001	3	10
BONE	Cilium or flagellum-dependent cell motility →	-0.081	-0.835	.001	<.001	3	10
BONE	Cilium-dependent cell motility →	-0.081	-0.835	.001	<.001	3	10
BONE	Sperm motility →	-0.090	-0.698	<.001	.001	3	9
BONE	Flagellated sperm motility →	-0.090	-0.698	<.001	.001	3	9
UPPER_AERODIGESTIVE_TRACT	Negative regulation of dopamine secretion →	+1.188	+1.226	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,836 associations by consensus.

Cilium movement involved in cell motility by IZUMO4 expression — LARGE_INTESTINE

Explore this box plot interactively →