Across TCGA cell cohorts, IZUMO3 RNA expression is significantly associated with the mutation status of many other genes, with 186 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible IZUMO3-associated genes across cancer lineages are DZANK1, NFATC1, and MRTFB. Each is linked with IZUMO3 in more than 1 cancer types. Because this analysis shows association rather than direction, both IZUMO3-to-partner and partner-to-IZUMO3 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IZUMO3→partner) and Y-score (partner→IZUMO3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	DZANK1 →	+4.652	+0.267	<.001	<.001	3	2
SKIN	NFATC1 →	+3.023	+0.487	.002	.001	3	2
BLOOD_Leukemia	MRTFB →	+4.384	+0.043	.006	<.001	3	2
BLOOD_Leukemia	PHF2 →	+4.969	+0.054	.003	<.001	3	2
LUNG_SCLC	NLRC5 →	+4.256	+0.499	.002	<.001	3	2
LUNG_NSCLC_LUAD	WDPCP →	+3.362	+0.019	.007	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 186 associations by consensus.

Exploration

IZUMO3 survival (RNA) · tumor vs normal (RNA) · all IZUMO3 data types