Across TCGA cell cohorts, IZUMO3 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible IZUMO3-associated genes across cancer lineages are SEPTIN14, SSMEM1, and VCX2. Each is linked with IZUMO3 in more than 1 cancer types. Because this analysis shows association rather than direction, both IZUMO3-to-partner and partner-to-IZUMO3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IZUMO3→partner) and Y-score (partner→IZUMO3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SEPTIN14 →	+0.009	+3.684	<.001	.006	3	1
LARGE_INTESTINE	SSMEM1 →	+0.032	+3.707	<.001	.009	3	1
LARGE_INTESTINE	VCX2 →	+1.369	+5.000	<.001	<.001	3	1
LARGE_INTESTINE	CLPSL1 →	+0.195	+4.054	<.001	.004	3	1
LARGE_INTESTINE	PRAMEF20 →	+0.012	+4.437	<.001	.004	3	1
LARGE_INTESTINE	MOG →	+0.157	+4.054	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

IZUMO3 survival (RNA) · tumor vs normal (RNA) · all IZUMO3 data types