IZUMO2

Across TCGA patient cohorts, IZUMO2 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,955 significant associations in total. STAD shows the largest number of these associations.

The most reproducible IZUMO2-associated GO terms across cancer lineages are Mitochondrial gene expression, Protein-RNA complex organization, and Mitochondrial respiratory chain complex assembly. Each is linked with IZUMO2 in more than 19 cancer types. Because this analysis shows association rather than direction, both IZUMO2-to-partner and partner-to-IZUMO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitochondrial gene expression grouped by IZUMO2-low versus IZUMO2-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IZUMO2→partner) and Y-score (partner→IZUMO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Mitochondrial gene expression →	+0.089	+0.533	<.001	<.001	3	20
STAD	Protein-RNA complex organization →	+0.065	+0.438	<.001	<.001	3	18
STAD	Mitochondrial respiratory chain complex assembly →	+0.069	+0.485	<.001	<.001	3	18
STAD	Mitochondrial transport →	+0.064	+0.414	<.001	<.001	3	18
ESCA	Macromolecule deacylation →	+0.066	+0.405	<.001	<.001	3	17
STAD	rRNA metabolic process →	+0.067	+0.373	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,955 associations by consensus.

Mitochondrial gene expression by IZUMO2 expression — ESCA

Explore this box plot interactively →