IZUMO2

Across TCGA patient cohorts, IZUMO2 protein abundance is significantly associated with the protein abundance of many other proteins, with 577 significant associations in total. GBM shows the largest number of these associations.

The most reproducible IZUMO2-associated proteins across cancer lineages are ATG2A_S1327, BIN2_S256, and BIN2_S273. Each is linked with IZUMO2 in more than 1 cancer types. Because this analysis shows association rather than direction, both IZUMO2-to-partner and partner-to-IZUMO2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IZUMO2 versus ATG2A_S1327 in GBM, with a Pearson correlation of 0.50.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IZUMO2→partner) and Y-score (partner→IZUMO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ATG2A_S1327 →	+0.420	+0.767	<.001	<.001	3	1
GBM	BIN2_S256 →	+0.913	+1.132	.003	<.001	3	1
GBM	BIN2_S273 →	+0.925	+1.108	.001	.001	3	1
GBM	BIN2_S447 →	+1.141	+0.756	.002	.005	3	1
GBM	ADA2 →	+0.575	+0.732	.003	<.001	3	1
GBM	C12orf29 →	-0.359	-0.740	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 577 associations by consensus.

IZUMO2 vs ATG2A_S1327 — GBM

Explore this scatter interactively →