IZUMO2

Across TCGA patient cohorts, IZUMO2 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IZUMO2-associated genes across cancer lineages are JNK2, p62 Lck ligand, and Tuberin. Each is linked with IZUMO2 in more than 1 cancer types. Because this analysis shows association rather than direction, both IZUMO2-to-partner and partner-to-IZUMO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by IZUMO2-low versus IZUMO2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IZUMO2→partner) and Y-score (partner→IZUMO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.259	+2.834	.009	.034	3	1
UCEC	p62 Lck ligand →	+0.517	+2.817	.001	.036	3	1
UCEC	Tuberin →	+0.388	+2.321	.004	.035	3	1
UCEC	4E-BP1 →	+0.332	+3.029	.014	.018	3	1
UCEC	Cyclin-B1 →	+0.564	+2.321	.045	.035	3	1
UCEC	MEK1 →	+0.477	+3.169	.009	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

JNK2 by IZUMO2 expression — UCEC

Explore this box plot interactively →