Across TCGA pan-cancer cohorts, IZUMO1R Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated IZUMO1R data layer compared with 21 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher IZUMO1R Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated IZUMO1R expression acts as an unfavorable survival marker.

COAD, LUAD, and GBM are the cancer types where IZUMO1R Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	All	0.111	0.871	<.001	24	view →
LUAD	OS	Median	All	0.250	0.837	<.001	18	view →
GBM	DFS	Median	All	0.048	0.257	.001	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: IZUMO1R tumor-vs-normal RNA expression · all IZUMO1R data types