IWS1

Across TCGA patient cohorts, IWS1 protein abundance is significantly associated with the RNA expression of many other genes, with 16,352 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IWS1-associated genes across cancer lineages are POLR1B, CCDC138, and NUP35. Each is linked with IWS1 in more than 7 cancer types. Because this analysis shows association rather than direction, both IWS1-to-partner and partner-to-IWS1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IWS1 versus POLR1B in OV, with a Pearson correlation of 0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IWS1→partner) and Y-score (partner→IWS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	POLR1B →	+0.716	+0.244	<.001	.001	3	8
LSCC	CCDC138 →	+0.774	+0.245	<.001	<.001	3	8
LSCC	NUP35 →	+0.607	+0.259	<.001	<.001	3	7
HNSC	PUM2 →	+0.510	+0.196	<.001	<.001	3	7
LSCC	ANAPC1 →	+0.630	+0.282	<.001	<.001	3	7
OV	SP4 →	+0.571	+0.287	.002	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,352 associations by consensus.

IWS1 vs POLR1B — OV

Explore this scatter interactively →