IWS1

Across TCGA cell cohorts, IWS1 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. OESOPHAGUS shows the largest number of these associations.

The most reproducible IWS1-associated genes across cancer lineages are SLC22A8, DCAF8L1, and DYTN. Each is linked with IWS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both IWS1-to-partner and partner-to-IWS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC22A8 grouped by IWS1-low versus IWS1-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IWS1→partner) and Y-score (partner→IWS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SLC22A8 →	+0.028	+4.432	<.001	<.001	3	1
OESOPHAGUS	DCAF8L1 →	+0.010	+3.584	<.001	.008	3	1
OESOPHAGUS	DYTN →	+0.086	+3.857	<.001	.002	3	1
OESOPHAGUS	KDM4E →	+0.029	+3.392	.001	.007	3	1
BLOOD_Lymphoma	AVP →	+0.031	+5.209	<.001	.005	3	1
LARGE_INTESTINE	ECE2 →	+0.336	+4.054	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

SLC22A8 by IWS1 expression — OESOPHAGUS

Explore this box plot interactively →