IVNS1ABP

Across TCGA pan-cancer cohorts, IVNS1ABP Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated IVNS1ABP data layer compared with 20 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher IVNS1ABP Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated IVNS1ABP expression acts as an unfavorable survival marker, although some lineages such as UCEC and STAD show a favorable association.

HNSC, ESCA, and SKCM are the cancer types where IVNS1ABP Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.223	0.665	<.001	60	view →
ESCA	OS	Median	II,III,IV	0.164	0.702	.001	33	view →
SKCM	OS	Median	All	0.138	0.871	<.001	24	view →
OV	OS	Median	II,III,IV	0.346	0.843	.003	18	view →
UCEC	DFS	Median	All	0.969	0.617	.005	14	view →
STAD	DFS	Median	II,III,IV	1.000	0.378	.045	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

IVNS1ABP–HNSC (OS)

Open the HNSC breakdown →