IVL

Across TCGA pan-cancer cohorts, IVL mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of IVL’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where IVL mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types IVL is over-expressed in tumor, although a few such as HNSC show the opposite, repressed pattern.

LSCC, HNSC, and LUAD are the cancer types where IVL tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IVL mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	All	III,IV	+1.910	<.001	9	view →
HNSC	Male	IV	−1.156	<.001	8	view →
LUAD	All	All	+0.537	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

IVL–LSCC

Open the LSCC breakdown →