IVL

Across TCGA patient cohorts, IVL mutation is significantly associated with the RNA expression of many other genes, with 2,811 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IVL-associated genes across cancer lineages are DHDDS, RASSF6, and SDHB. Each is linked with IVL in more than 2 cancer types. Because this analysis shows association rather than direction, both IVL-to-partner and partner-to-IVL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DHDDS grouped by IVL-low versus IVL-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IVL→partner) and Y-score (partner→IVL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	DHDDS →	+0.468	+3.845	<.001	<.001	3	3
UCEC	RASSF6 →	+0.873	+2.247	.001	.002	3	3
UCEC	SDHB →	+0.362	+2.736	.007	<.001	3	3
UCEC	TRIM25 →	+0.396	+2.740	.007	.003	3	3
UCEC	RPP30 →	+0.407	+2.831	.003	.001	3	3
UCEC	DPH3 →	+0.435	+1.858	.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,811 associations by consensus.

DHDDS by IVL expression — SKCM

Explore this box plot interactively →